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Objective To analyze the anxiety and depression state in housebound elderly subjects and their influencing factors so as to provide theoretical basis for improving the psychological status of the elderly.Methods Three hundred and fifty elderly patients aged ＞ 60 years suffering from anxiety and depression in two communities of Beijing were clusterly sampled and analyzed.The basic information of housebound elderly subjects with anxiety and depression was recorded during questionnaire survey.The influencing factors for anxiety and depression were explored by using the anxiety self-assessment scale and depression self-rating scale.Results Based on univariable analysis,the factors influencing anxiety and depression of the housebound elderly included ageing,lower cultural level,low income,infrequency of offspring visit and friends meeting,lost spouse,chronic diseases,many medications,and the unsatisfactory living environment(all P ＜ 0.05).However,the participating of entertainment activity and religious beliefs were not influencing factors(all P ＞ 0.05).Logistic multivariate regression showed that women (OR =1.432,95％CI:1.236 1.684,P＜0.05),low income(OR =2.078,95％ CI:1.675 2.412,P＜0.05),the widowed(OR =2.342,95 ％ CI:1.857-2.769,P ＜ 0.05),chronic diseases (OR =2.078,95 ％ CI:1.674-2.531,P＜0.05),medication (OR =3.056,95 ％ CI:2.678 3.756,P ＜ 0.05),less visit by children (OR =2.898,95％CI:2.475 3.425,P＜0.05),less friends visiting(OR=1.965,95％CI:1.685-2.446,P＜0.05) were risk factors for anxiety in the elderly.Meanwhile,women (OR =3.221,95 ％ CI:2.674-3.853,P ＜ 0.05),low income (OR =2.342,95 ％ CI:1.768-2.754,P ＜ 0.05),chronic disease (OR =2.078,95 ％ CI:1.564 2.675,P＜0.05),the widowed(OR=2.223,95％CI:1.789 2.746,P＜0.05),less visit by children (OR=2.987,95％CI:2.463-3.524,P＜0.05),less friends visiting(OR=2.658,95％CI:2.242 3.168,P＜0.05) and poor satisfaction with surrounding environment(OR =1.765,95 ％ CI:1.375 2.371,P＜0.05) were risk factors for depression among the elderly.Conclusions The elderly,especially those with advanced age,low cultural level,low economic income,living alone and poor living environment,are more likely to have anxiety and depression.Therefore,some effective corresponding measures should be taken in order to improve the psychological condition and life quality of old people.
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A nuclear accident likely leads to the leakage of radiocesium to a large degree,which could poses threatens to the environment and human heahh.Hence,it is very important to remove radiocesium ion from the environment and human body in the aftermath of a nuclear accident.In this review,the new progress of radiocesium ion removal in a nuclear emergency is discussed.The main technique to reduce soil pollution is to remove and purify topsoil.The methods of purification include leaching method,electrokinetic process and soil immobilization.The technique to remove radiocesium from water is mainly via adsorption.Common adsorbents include crown ether,calix ether,ammonium molybdophosphate and Prussian blue.Radiocesium removal from human body is mainly via oral administration of Prussian blue at fractioned doses in a timely manner but spents a relatively long response time,possibly accompanied with some severe side effects,like hypopotassemia and physical damage of digestive tract.Therefore,new techniques are still in need of development to remove radiocesium ion from human body more effectively.
ABSTRACT
Objective To analyze the anxiety and depression state in housebound elderly subjects and their influencing factors so as to provide theoretical basis for improving the psychological status of the elderly.Methods Three hundred and fifty elderly patients aged ＞ 60 years suffering from anxiety and depression in two communities of Beijing were clusterly sampled and analyzed.The basic information of housebound elderly subjects with anxiety and depression was recorded during questionnaire survey.The influencing factors for anxiety and depression were explored by using the anxiety self-assessment scale and depression self-rating scale.Results Based on univariable analysis,the factors influencing anxiety and depression of the housebound elderly included ageing,lower cultural level,low income,infrequency of offspring visit and friends meeting,lost spouse,chronic diseases,many medications,and the unsatisfactory living environment(all P ＜ 0.05).However,the participating of entertainment activity and religious beliefs were not influencing factors(all P ＞ 0.05).Logistic multivariate regression showed that women (OR =1.432,95％CI:1.236 1.684,P＜0.05),low income(OR =2.078,95％ CI:1.675 2.412,P＜0.05),the widowed(OR =2.342,95 ％ CI:1.857-2.769,P ＜ 0.05),chronic diseases (OR =2.078,95 ％ CI:1.674-2.531,P＜0.05),medication (OR =3.056,95 ％ CI:2.678 3.756,P ＜ 0.05),less visit by children (OR =2.898,95％CI:2.475 3.425,P＜0.05),less friends visiting(OR=1.965,95％CI:1.685-2.446,P＜0.05) were risk factors for anxiety in the elderly.Meanwhile,women (OR =3.221,95 ％ CI:2.674-3.853,P ＜ 0.05),low income (OR =2.342,95 ％ CI:1.768-2.754,P ＜ 0.05),chronic disease (OR =2.078,95 ％ CI:1.564 2.675,P＜0.05),the widowed(OR=2.223,95％CI:1.789 2.746,P＜0.05),less visit by children (OR=2.987,95％CI:2.463-3.524,P＜0.05),less friends visiting(OR=2.658,95％CI:2.242 3.168,P＜0.05) and poor satisfaction with surrounding environment(OR =1.765,95 ％ CI:1.375 2.371,P＜0.05) were risk factors for depression among the elderly.Conclusions The elderly,especially those with advanced age,low cultural level,low economic income,living alone and poor living environment,are more likely to have anxiety and depression.Therefore,some effective corresponding measures should be taken in order to improve the psychological condition and life quality of old people.
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Objective To report 2 cases of Epstein-Barr virus-associated cutaneous lymphoproliferative disease (LPD) and to evaluate their relationship with chronic active Epstein-Barr virus (CAEBV) infection.Methods The clinical data on, laboratory examination findings in, treatment and therapeutic response of 2cases of LPD were analyzed. Results Both the patients had chronic intermittent fever, lymphadenopathy, recurrent lesions including papules, papulovesicles, necrosis and variola-like scar in light-exposed and unexposed areas. Pathologically, there was a dermal infiltrate of pleomorphic lymphoid cells with the involvement of perivascular area and some subcutaneous tissue. Immunohistochemical staining showed that most of the infiltrating lymphoid cells were positive for CD8, PCR revealed no TCR-γ gene rearrangement, and in situ hybridization for EBV was positive. The copy of EBV DNA was above the normal range in the peripheral blood from both patients. Clinical status was improved after glucocorticoid treatment. Conclusion The biologic behavior of LPD appears to be a chronic and indolent course and is closely associated with CAEBV.
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Objective To establish a fluorescent quantitative polymerase chain reaction method for quantifying the ICP4 gene expression of herpes simplex virus type 2(HSV2).Methods According to the HSV2 ICP4 gene sequence,we designed and synthesized PCR primer.The purified PCR product was sequenced after connecting with pMD-18 T plasmid.According to the sequence assay results,the primer and probe of fluorescent quantitative PCR was designed and synthesized.Standard recombinant plasmid extracted from the positive bacteriumclone was used as standard substance.The plasmid as standard substance was diluted for 10 times,then PCR reaction proceeded.The sensitivity and dependability of the real-time fluorescent quantitative PCR were analyzed.Results The sequence result indicated that there was non-sense mutation of A-G and T-C.And the detection sensitivity was 101 copy.The Ct value were 14.275土0.137,17.988?0.162,22.081土0.259,25.957土0.345,29.565?0.203,33.269土0.287,37.737?0.698,respectively with 107~ 101 copies/?l.The coefficient of variability were 0.965%,0.902%,1.174%,1.329%,0.686%,0.862% and1.851%,respectively.There was a good linear function in statistics between the Ct value and the concentration gradient of standard plasmid DNA specimen.The coefficient of regression was 0.998.Conclusion The method of quantification of ICP4 gene of HSV2 with real-time fluorescent quantitative PCR is successfully established,and the method has good sensitivity and dependability,which can be used to quantitative detecting HSV2 ICP4.